منابع مشابه
Therapeutic Targets in Heart Failure
From the *Heart Pittsburgh Schoo Cardiomyopathy C California; zCente School of Medici University, Atlanta Siemens; has receiv purposes; and has r The Pittsburgh F GlaxoSmithKline, Relypsa, Scios, St. as the Eliot Cord Ahmanson Found ew therapeutic targets, agents, and strategies are needed to prevent and treat heart failure (HF) after a decade of failed research efforts to improve long-term pat...
متن کاملAnemia and iron deficiency--new therapeutic targets in heart failure?
Anemia ranges in prevalence from below 10% among patients with mild heart failure symptoms to over 40% for patients with advanced disease.1 Its prevalence is similar among patients who have systolic dysfunction and among patients who have heart failure with preserved systolic function.2,3 Anemia has been associated with older age, diabetes mellitus, chronic renal dysfunction, more advanced hear...
متن کاملToll-like receptors: emerging therapeutic targets for heart failure
Toll-like receptors (TLRs) have been identified as central innate immune receptors. They distinguish among different patterns of pathogens and rapidly activate an innate immune response. However, TLRs can also be stimulated by host-derived molecules. They are expressed in the cardiovascular system and could thus be a key link between cardiovascular diseases and the activation of the immune syst...
متن کاملTherapeutic Strategies in Heart Failure
Clyde W. Yancy and James B. Young, eds 256 pages. Oxford, UK: Clinical Publishing; 2008. $77.00. ISBN 1–904392–40–7 The sobering statistics on heart failure in the United States are often repeated: the incidence approaches 10 per 1000 population after 65 years of age; the lifetime risk for both men and women over age 40 is 1 in 5; 1.1 million hospital discharges occur per year, with estimated c...
متن کاملTargets in Ischemia and Heart Failure?
Purinergic1 receptors were initially conceived to describe the likely existence of membrane receptors responding to adenosine triphosphate (ATP) (P2 receptors) or its breakdown product adenosine (P1 receptors) in causing nonadrenergic, noncholinergic relaxation of gut smooth muscle.1 Cloning of these receptors has yielded insights into their properties and signaling mechanisms, allowing classif...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2014
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2014.01.068